:root {
  --bg: #f3f4f6;
  --paper: #ffffff;
  --ink: #1a1d23;
  --muted: #5c6570;
  --line: #d8dce3;
  --accent: #1d4ed8;
  --warn: #b45309;
  --stub: #4b5563;
  --sidebar-w: 15.5rem;
  --font: "Segoe UI", "Helvetica Neue", Arial, sans-serif;
  --sans: var(--font);
}
* { box-sizing: border-box; }
html { font-size: 15.5px; }
body {
  margin: 0;
  background: var(--bg);
  color: var(--ink);
  font-family: var(--font);
  line-height: 1.4;
}
.wiki { display: flex; min-height: 100vh; }
.sidebar {
  width: var(--sidebar-w);
  flex-shrink: 0;
  padding: 1rem 0.85rem 1.75rem;
  border-right: 1px solid var(--line);
  background: #eef0f3;
  position: sticky;
  top: 0;
  height: 100vh;
  overflow-y: auto;
}
.brand { font-family: var(--sans); font-weight: 650; font-size: 0.92rem; margin-bottom: 0.85rem; }
.brand a { color: var(--ink); text-decoration: none; }
.search-label { font-family: var(--sans); font-size: 0.68rem; text-transform: uppercase; letter-spacing: 0.04em; color: var(--muted); }
#wiki-search {
  width: 100%;
  margin: 0.2rem 0 0.65rem;
  padding: 0.35rem 0.45rem;
  border: 1px solid var(--line);
  border-radius: 3px;
  font: inherit;
  background: var(--paper);
}
.search-results {
  font-family: var(--sans);
  font-size: 0.82rem;
  margin-bottom: 0.65rem;
  background: var(--paper);
  border: 1px solid var(--line);
  border-radius: 3px;
  max-height: 12rem;
  overflow: auto;
}
.search-results a {
  display: block;
  padding: 0.3rem 0.45rem;
  color: var(--accent);
  text-decoration: none;
  border-bottom: 1px solid var(--line);
}
.search-results a:last-child { border-bottom: 0; }
.nav-group { margin-bottom: 0.65rem; }
.nav-domain {
  font-family: var(--sans);
  font-size: 0.76rem;
  font-weight: 650;
  letter-spacing: 0.02em;
  margin: 0.85rem 0 0.3rem;
  color: var(--ink);
}
.nav-domain:first-child { margin-top: 0; }
.nav-disease {
  font-family: var(--sans);
  font-size: 0.7rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--muted);
  margin-bottom: 0.2rem;
}
.disease-h { font-size: 0.95rem; margin: 0.85rem 0 0.2rem; color: var(--muted); font-family: var(--sans); font-weight: 600; }
.nav ul { list-style: none; margin: 0; padding: 0; }
.nav li { margin: 0.12rem 0; font-size: 0.88rem; }
.nav a { color: var(--ink); text-decoration: none; }
.nav a:hover { color: var(--accent); }
.nav li.active > a { font-weight: 650; color: var(--accent); }
.nav li.planned { color: var(--muted); font-size: 0.82rem; }
.sidebar-foot { font-family: var(--sans); font-size: 0.78rem; color: var(--muted); margin-top: 1.25rem; }
.sidebar-foot a { color: var(--muted); }
.main {
  flex: 1;
  max-width: 58rem;
  padding: 1.25rem 1.75rem 2.5rem;
  background: var(--paper);
  min-height: 100vh;
  border-right: 1px solid var(--line);
}
.page-head h1 { font-size: 1.45rem; line-height: 1.2; margin: 0.15rem 0 0.35rem; font-weight: 650; }
.lede { color: var(--muted); margin-top: 0; }
.crumb { font-family: var(--sans); font-size: 0.76rem; color: var(--muted); margin: 0; }
.crumb a { color: var(--muted); }
.meta-line, .status-line, .meta { font-family: var(--sans); font-size: 0.8rem; color: var(--muted); }
.section-toc {
  position: sticky;
  top: 0;
  z-index: 5;
  margin: 0.65rem 0 0.85rem;
  padding: 0.4rem 0.55rem;
  border: 1px solid var(--line);
  border-radius: 3px;
  background: #f8f9fb;
  font-family: var(--sans);
  font-size: 0.76rem;
  line-height: 1.3;
}
.section-toc-label {
  display: block;
  font-size: 0.65rem;
  font-weight: 650;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  color: var(--muted);
  margin-bottom: 0.25rem;
}
.section-toc-links {
  display: flex;
  flex-wrap: wrap;
  gap: 0.15rem 0.55rem;
}
.section-toc-links a {
  color: var(--accent);
  text-decoration: none;
  white-space: nowrap;
}
.section-toc-links a:hover { text-decoration: underline; }
.pill {
  font-family: var(--sans);
  font-size: 0.62rem;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  padding: 0.08rem 0.3rem;
  border-radius: 2px;
  border: 1px solid var(--line);
  color: var(--stub);
  vertical-align: middle;
}
.pill.stale { color: var(--warn); border-color: #fcd34d; background: #fffbeb; }
.pill.stub { background: #f3f4f6; }
.pill.muted { color: var(--muted); }
.start-here, .home-section { margin: 1.4rem 0; }
.start-here { padding: 0.65rem 0.85rem; border: 1px solid var(--line); border-radius: 3px; background: #f8f9fb; }
.start-here h2, .home-section h2 { font-size: 1.05rem; margin-top: 0; }
.article-list { list-style: none; padding: 0; margin: 0; }
.article-list li {
  padding: 0.5rem 0;
  border-bottom: 1px solid var(--line);
}
.article-list .meta { display: block; margin-top: 0.1rem; }
.article-list .blurb { font-size: 0.88rem; color: var(--muted); }
.article-list li.planned { opacity: 0.65; }
.evidence h2 { font-size: 1.05rem; margin-top: 1.35rem; border-bottom: 1px solid var(--line); padding-bottom: 0.2rem; }
.evidence h3 { font-size: 0.95rem; margin-top: 1rem; }
.evidence ul, .evidence ol, .phrase-body, .start-here ul { padding-left: 1.1rem; }
.evidence li, .phrase-body li { margin: 0.18rem 0; }
.evidence ol.sources { list-style: decimal; padding-left: 1.4rem; }
.evidence ol.sources li { scroll-margin-top: 4.5rem; }
.evidence sup.cite { font-size: 0.72em; line-height: 0; vertical-align: super; }
.evidence a.cite-ref { color: var(--accent); text-decoration: none; font-weight: 650; }
.evidence a.cite-ref:hover { text-decoration: underline; }
.table-wrap { overflow-x: auto; margin: 0.55rem 0 0.95rem; }
.evidence table { width: 100%; border-collapse: collapse; font-family: var(--sans); font-size: 0.74rem; line-height: 1.32; }
.evidence th, .evidence td { border: 1px solid var(--line); padding: 0.28rem 0.4rem; text-align: left; vertical-align: top; }
.evidence th { background: #e8ebf0; font-weight: 700; color: #111827; }
.table-wrap.cross_trial {
  padding: 0.25rem;
  border: 1px solid #bfdbfe;
  border-left: 4px solid var(--accent);
  border-radius: 3px;
  background: #eff6ff;
}
.table-wrap.cross_trial table { min-width: 64rem; background: var(--paper); }
.table-wrap.cross_trial th { background: #dbeafe; color: #1e3a8a; }
.table-wrap.cross_trial td:first-child {
  min-width: 8rem;
  font-weight: 650;
  color: #1e3a8a;
  background: #f8fbff;
}
.table-wrap.cross_trial tbody tr:nth-child(even) td { background: #fcfdff; }
.table-wrap.cross_trial tbody tr:hover td { background: #f0f7ff; }
.evidence-figure { margin: 0.7rem 0 1rem; padding: 0.5rem; border: 1px solid var(--line); background: #f8f9fb; }
.evidence-figure img { display: block; width: 100%; height: auto; }
.related { font-family: var(--sans); font-size: 0.8rem; margin: 0.55rem 0 0; }
.related a { color: var(--accent); }
.phrase {
  margin-top: 1.75rem;
  padding-top: 0.85rem;
  border-top: 2px solid var(--line);
}
.phrase-head { display: flex; align-items: center; justify-content: space-between; gap: 1rem; }
.phrase-head h2 { margin: 0; font-size: 1.05rem; }
.trigger { font-family: var(--sans); }
.phrase-tools {
  margin: 0.85rem 0;
  padding: 0.75rem 0.85rem;
  border: 1px solid var(--line);
  border-radius: 3px;
  background: #f8f9fb;
  font-family: var(--sans);
}
.phrase-tools h3, .phrase-calculator h4 { margin: 0; font-size: 0.9rem; }
.phrase-tools-note, .calculator-note, .calculator-result {
  margin: 0.3rem 0 0;
  color: var(--muted);
  font-size: 0.76rem;
}
.phrase-tools-grid { display: grid; gap: 0.7rem; margin-top: 0.7rem; }
.phrase-control { display: grid; gap: 0.25rem; }
.phrase-control label, .calculator-field label { font-size: 0.78rem; font-weight: 650; }
.phrase-control select, .calculator-field select {
  width: 100%;
  padding: 0.35rem 0.45rem;
  border: 1px solid var(--line);
  border-radius: 3px;
  color: var(--ink);
  background: var(--paper);
  font: inherit;
}
.phrase-calculator {
  padding: 0.7rem;
  border: 1px solid var(--line);
  border-radius: 3px;
  background: var(--paper);
}
.calculator-fields { display: grid; gap: 0.55rem; margin-top: 0.65rem; }
.calculator-field { display: grid; gap: 0.25rem; }
.calculator-result { color: var(--ink); font-weight: 650; }
.phrase-fill-in {
  color: var(--accent);
  font-family: var(--sans);
  font-size: 0.92em;
  font-weight: 650;
}
.copy-btn {
  font-family: var(--sans);
  font-size: 0.76rem;
  padding: 0.3rem 0.6rem;
  border: 1px solid var(--line);
  background: var(--bg);
  border-radius: 3px;
  cursor: pointer;
}
.copy-btn:hover { border-color: var(--accent); color: var(--accent); }
.copy-btn.copied { border-color: #15803d; color: #15803d; }
.src { font-family: var(--sans); font-size: 0.76rem; color: var(--muted); }
.src a { color: var(--muted); }
.gen-note { font-family: var(--sans); font-size: 0.72rem; color: var(--muted); margin-top: 2rem; }
.inbox-item { margin: 1.25rem 0; padding-bottom: 0.85rem; border-bottom: 1px solid var(--line); }
.sr-only {
  position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px;
  overflow: hidden; clip: rect(0,0,0,0); border: 0;
}
code { font-family: ui-monospace, SFMono-Regular, Menlo, monospace; font-size: 0.88em; }
@media (max-width: 800px) {
  .wiki { flex-direction: column; }
  .sidebar {
    width: 100%;
    height: auto;
    position: relative;
    border-right: 0;
    border-bottom: 1px solid var(--line);
  }
  .main { border-right: 0; max-width: none; padding: 1rem; }
  .section-toc { position: static; }
}